Hydrochloric Acid → Ethyl 1-(4-fluorobenzoyl)4-oxo-3-piperidinecarboxylate

HRID 817821Notes

Reaction equation

HRID 817821 reaction equation
[C:1]([N:2]1[CH2:3][CH2:4][CH2:5][CH:6]([C:7]([O:8][CH2:9][CH3:10])=[O:11])[CH2:12]1)(=[O:13])[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1.[CH:33]([N:34]([CH:35]([CH3:36])[CH3:37])[CH2:38][CH3:39])([CH3:40])[CH3:41].[ClH:20].[F:42][c:43]1[cH:44][cH:45][c:46]([C:47](=[O:48])[Cl:49])[cH:50][cH:51]1.[NH:21]1[CH2:22][CH:23]([C:28](=[O:29])[O:30][CH2:31][CH3:32])[C:24](=[O:27])[CH2:25][CH2:26]1>>[N:21]1([C:47]([c:46]2[cH:45][cH:44][c:43]([F:42])[cH:51][cH:50]2)=[O:48])[CH2:22][CH:23]([C:28](=[O:29])[O:30][CH2:31][CH3:32])[C:24](=[O:27])[CH2:25][CH2:26]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 678794-Fluorobenzoyl chlorideHCID 81531DiisopropylethylamineHCID 1073164-Oxo-piperidine-3-carboxylic acid ethyl esterHCID 3784394Ethyl 1-benzoyl-3-piperidinecarboxylate

Product 1

HCID 18760280Ethyl 1-(4-fluorobenzoyl)4-oxo-3-piperidinecarboxylate

Sources & evidence

ORD record
ord-88f5b8c871fa4680a96baf1ee6af788e
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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