Bicarbonate Ion → 4-(3-chloroanilino)-6-cyano-7H-pyrrolo[2,3-d]pyrimidine

HRID 817938Notes

Reaction equation

HRID 817938 reaction equation
[CH3:31][N:32]([CH3:33])[C:34](=[O:35])[CH3:36].[NH2:6][C:7](=[O:8])[c:9]1[cH:10][c:11]2[c:12]([n:13][cH:14][n:15][c:16]2[NH:17][c:18]2[cH:19][c:20]([Cl:24])[cH:21][cH:22][cH:23]2)[nH:25]1.[Na+:30].[O-:26][C:27]([OH:28])=[O:29].[P:1]([Cl:2])([Cl:3])([Cl:4])=[O:5]>>[N:6]#[C:7][c:9]1[cH:10][c:11]2[c:12]([n:13][cH:14][n:15][c:16]2[NH:17][c:18]2[cH:19][c:20]([Cl:24])[cH:21][cH:22][cH:23]2)[nH:25]1

Participants

6

Reactant 5

HCID 769Bicarbonate IonHCID 923Sodium ionHCID 24813Phosphorus oxychlorideHCID 31374DimethylacetamideHCID 212626756-aminocarbonyl-4-(3-chloroanilino)-7H-pyrrolo[2,3-d]pyrimidine

Product 1

HCID 212626714-(3-chloroanilino)-6-cyano-7H-pyrrolo[2,3-d]pyrimidine

Sources & evidence

ORD record
ord-0f76aca2a5d74671a9f6369140e14ec7
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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