Hydrochloric Acid → 2-[(4-Chloro-1-hydroxy-naphthalene-2-carbonyl)-amino]-2-methyl-propionic acid tert-butyl ester

HRID 818179Notes

Reaction equation

HRID 818179 reaction equation
[C:17]([CH3:18])([CH3:19])([CH3:20])[O:21][C:22]([C:23]([CH3:24])([CH3:25])[NH2:26])=[O:27].[CH3:53][N:54]([CH3:55])[CH:56]=[O:57].[Cl:1][c:2]1[cH:3][c:4]([C:13](=[O:14])[OH:15])[c:5]([OH:12])[c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]12.[ClH:16].[OH2:52].[P-:28]([F:29])([F:30])([F:31])([F:32])([F:33])[F:34].[n:35]1([O:36][C:37]([N:38]([CH3:39])[CH3:40])=[N+:41]([CH3:42])[CH3:43])[c:44]2[n:45][cH:46][cH:47][cH:48][c:49]2[n:50][n:51]1>>[Cl:1][c:2]1[cH:3][c:4]([C:13](=[O:15])[NH:26][C:23]([C:22]([O:21][C:17]([CH3:18])([CH3:19])[CH3:20])=[O:27])([CH3:24])[CH3:25])[c:5]([OH:12])[c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]12

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 962WaterHCID 6228DimethylformamideHCID 9886HexafluorophosphateHCID 794164-Chloro-1-hydroxy-2-naphthoic acidHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 7019940tert-Butyl 2-methylalaninate

Product 1

HCID 667011662-[(4-Chloro-1-hydroxy-naphthalene-2-carbonyl)-amino]-2-methyl-propionic acid tert-butyl ester

Sources & evidence

ORD record
ord-83c88709969d4528ab2661f5297913e7
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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