1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → 4-bromo-1'-[3-[2-(trifluoromethyl)phenyl]prop-2-enoyl]spiro[2H-isoindole-3,4'-piperidine]-1-one

HRID 818632Notes

Reaction equation

[Br:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[c:10]1[C:9]1([NH:8][C:7]2=[O:16])[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]1.[CH3:32][CH2:33][N:34]=[C:35]=[N:36][CH2:37][CH2:38][CH2:39][N:40]([CH3:41])[CH3:42].[F:17][C:18]([c:19]1[c:20]([CH:25]=[CH:26][C:27](=[O:28])[OH:29])[cH:21][cH:22][cH:23][cH:24]1)([F:30])[F:31].[OH:43][n:44]1[c:45]2[c:46]([cH:47][cH:48][cH:49][cH:50]2)[n:51][n:52]1>>[Br:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[c:10]1[C:9]1([NH:8][C:7]2=[O:16])[CH2:11][CH2:12][N:13]([C:27]([CH:26]=[CH:25][c:20]2[c:19]([C:18]([F:17])([F:30])[F:31])[cH:24][cH:23][cH:22][cH:21]2)=[O:28])[CH2:14][CH2:15]1