反应详情

温度

-78 °C

Benzyloxy-acetaldehyde (3.0 g, 20 mmol) is dissolved in tetrahydrofuran (200 mL), cooled to −78° C. This solution is treated with phenylethylmagnesium chloride (1.0 M in tetrahydrofuran, 24 mL, 24 mmol), and stirred for one hour. The mixture is allowed to warm to room temperature and stirred for 4 h. The mixture is treated with hydrochloric acid (1 M, 40 mL) and extracted with ethyl acetate. The combined organic extracts are washed with water and brine, dried over sodium sulfate, and filtered. The filtrate is concentrated in vacuo to provide the title compound, 4.0 g (80%), as a colorless liquid.

1. temperatureto warm to room temperature
2. stirringstirred for 4 h
3. extractionextracted with ethyl acetate
4. washThe combined organic extracts are washed with water and brine
5. dry with materialdried over sodium sulfate
6. filtrationfiltered
7. concentrationThe filtrate is concentrated in vacuo