反应详情

A Parr vessel was charged with 2-methyl-1-[(3-nitro[1,5]naphthyridin-4-yl)amino]propan-2-ol (44.12 g, 0.17 mol), 5% Pt/C (4.4 g) and isopropyl alcohol (890 mL). The vessel was placed under hydrogen pressure (35 psi, 2.4×105 Pa) until hydrogen uptake ceased. The reaction mixture was filtered through a layer of filter aid. The filter cake was rinsed with additional isopropyl alcohol. The filtrate was concentrated under reduced pressure to provide 1-[(3-amino[1,5]naphthyridin-4-yl)amino]-2-methylpropan-2-ol as a thick oil.

1. filtrationThe reaction mixture was filtered through a layer of filter aid
2. washThe filter cake was rinsed with additional isopropyl alcohol
3. concentrationThe filtrate was concentrated under reduced pressure