2,6-Diethylaniline → 8-Amino-N-(2,6-diethylphenyl)-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide

Temperature

0 °C

Sodium hexamethyldisilazide (NaHMDS) in THF (1.0 M, 11.0 mL, 11.0 mmol) was added over 30 min to a solution of 2,6-diethylaniline (1.2 mL, 8.32 mmol) and ethyl 8-amino-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate (0.760 g, 2.77 mmol) in THF (30 mL) at 0° C. The resulting brown solution was stirred at 0° C. for 10 min and allowed to warm to room temperature over a period of 30 min. After stirring at room temperature for 3 h, the reaction was quenched by the addiction of saturated acquesous NH4Cl (10 mL). The reaction was partitioned between ethyl acetate (50 mL) and water (50 mL). The acqueos layer was extracted with ethyl acetate (2×30 mL). The combined organic solution was washed with brine (50 mL), dried over Na2SO4, filtered and evaporated to dryness, the crude solid was purified by flash chromatography on silica gel (eluant: dichloromethane/methanol 95/5) to afford 0.830 g (80% yield) of the title compound.

1. temperatureto warm to room temperature over a period of 30 min
2. stirringAfter stirring at room temperature for 3 h
3. customthe reaction was quenched by the addiction of saturated acquesous NH4Cl (10 mL)
4. customThe reaction was partitioned between ethyl acetate (50 mL) and water (50 mL)
5. extractionThe acqueos layer was extracted with ethyl acetate (2×30 mL)
6. washThe combined organic solution was washed with brine (50 mL)
7. dry with materialdried over Na2SO4
8. filtrationfiltered
9. customevaporated to dryness
10. customthe crude solid was purified by flash chromatography on silica gel (eluant: dichloromethane/methanol 95/5)

ORD record

ord-597af241cbeb408ea88761810cd93bdf

Source dataset

uspto-grants-2014_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08846701B2