Sodium ion → 2,5-Dichloro-4-(6-methylsulfanylbenzo[b]thiophen-2-yl)-pyrimidine

HRID 819971Notes

Reaction equation

HRID 819971 reaction equation
[C:33](=[O:34])([O-:35])[O-:36].[CH2:48]1[O:49][CH2:50][CH2:51][CH2:52]1.[CH3:1][S:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([s:8][cH:9][cH:10]2)[cH:11]1.[CH:12]([O:13][B:14]([O:15][CH:16]([CH3:17])[CH3:18])[O:19][CH:20]([CH3:21])[CH3:22])([CH3:23])[CH3:24].[CH:25]([NH:26][CH:27]([CH3:28])[CH3:29])([CH3:30])[CH3:31].[Cl:39][c:40]1[n:41][cH:42][c:43]([Cl:47])[c:44]([Cl:46])[n:45]1.[Li:32].[Na+:37].[Na+:38]>>[CH3:1][S:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([s:8][c:9](-[c:44]3[c:43]([Cl:47])[cH:42][n:41][c:40]([Cl:39])[n:45]3)[cH:10]2)[cH:11]1

Participants

9

Reactant 8

HCID 923Sodium ion2×HCID 7912DiisopropylamineHCID 8028TetrahydrofuranHCID 19660Carbonate IonHCID 21531Triisopropyl borateHCID 2372592,4,5-TrichloropyrimidineHCID 3028194LithiumHCID 198037266-Methylsulfanylbenzo[b]thiophene

Product 1

HCID 866253562,5-Dichloro-4-(6-methylsulfanylbenzo[b]thiophen-2-yl)-pyrimidine

Sources & evidence

ORD record
ord-e9d453ac3b694b3a864ec6065bd1ce70
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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