Tetrahydrofuran → [1-(4-Methoxy-benzyl)-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl]-acetic acid tert-butyl ester

HRID 820194Notes

Reaction equation

HRID 820194 reaction equation
[Br:29][CH2:30][C:31](=[O:32])[O:33][C:34]([CH3:35])([CH3:36])[CH3:37].[CH2:38]1[O:39][CH2:40][CH2:41][CH2:42]1.[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([CH2:7][N:8]2[C:9](=[O:18])[CH2:10][CH2:11][c:12]3[cH:13][cH:14][cH:15][cH:16][c:17]32)[cH:19][cH:20]1.[CH3:22][CH:23]([N-:24][CH:25]([CH3:26])[CH3:27])[CH3:28].[Li+:21]>>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([CH2:7][N:8]2[C:9](=[O:18])[CH:10]([CH2:30][C:31](=[O:32])[O:33][C:34]([CH3:35])([CH3:36])[CH3:37])[CH2:11][c:12]3[cH:13][cH:14][cH:15][cH:16][c:17]32)[cH:19][cH:20]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 79177tert-Butyl bromoacetateHCID 5062348DiisopropylamideHCID 547654001-[(4-Methoxyphenyl)methyl]-3,4-dihydroquinolin-2(1H)-one

Product 1

HCID 69009889[1-(4-Methoxy-benzyl)-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl]-acetic acid tert-butyl ester

Sources & evidence

ORD record
ord-177847ab0ea84c4992ae89fe6d06816c
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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