Hydrochloric Acid → 2-(4-(4-((6-Chloropyridazin-3-yl)sulfonyl)piperazin-1-yl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

HRID 820400Notes

Reaction equation

HRID 820400 reaction equation
[C:43](=[O:44])([OH:45])[O-:46].[CH3:36][CH2:37][N:38]([CH2:39][CH3:40])[CH2:41][CH3:42].[Cl:25][c:26]1[cH:27][cH:28][c:29]([S:32](=[O:33])(=[O:34])[Cl:35])[n:30][n:31]1.[Cl:48][CH2:49][Cl:50].[ClH:1].[ClH:2].[F:3][C:4]([C:5]([C:6]([F:7])([F:8])[F:9])([OH:10])[c:11]1[cH:12][cH:13][c:14]([N:17]2[CH2:18][CH2:19][NH:20][CH2:21][CH2:22]2)[cH:15][cH:16]1)([F:23])[F:24].[Na+:47]>>[F:3][C:4]([C:5]([C:6]([F:7])([F:8])[F:9])([OH:10])[c:11]1[cH:12][cH:13][c:14]([N:17]2[CH2:18][CH2:19][N:20]([S:32]([c:29]3[cH:28][cH:27][c:26]([Cl:25])[n:31][n:30]3)(=[O:33])=[O:34])[CH2:21][CH2:22]2)[cH:15][cH:16]1)([F:23])[F:24]

Participants

8

Reactant 7

HCID 313Hydrochloric Acid2×HCID 769Bicarbonate IonHCID 923Sodium ionHCID 6344DichloromethaneHCID 8471TriethylamineHCID 616113006-Chloropyridazine-3-sulfonyl chlorideHCID 866237611,1,1,3,3,3-Hexafluoro-2-(4-(1-piperazinyl)phenyl)-2-propanol

Product 1

HCID 569326312-(4-(4-((6-Chloropyridazin-3-yl)sulfonyl)piperazin-1-yl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

Sources & evidence

ORD record
ord-626bf4055d7043cfae1fa53c7e6e4cbb
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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