Methane → tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylate

HRID 820410Notes

Reaction equation

HRID 820410 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([O:14][c:15]2[cH:16][cH:17][c:18]([N+:21]([O-:22])=[O:23])[cH:19][cH:20]2)[CH2:12][CH2:13]1.[C:32].[CH3:29][CH2:30][OH:31].[O:24]1[CH2:25][CH2:26][CH2:27][CH2:28]1.[Pd:33]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([O:14][c:15]2[cH:16][cH:17][c:18]([NH2:21])[cH:19][cH:20]2)[CH2:12][CH2:13]1

Participants

6

Reactant 5

HCID 297MethaneHCID 702EthanolHCID 8028TetrahydrofuranHCID 23938PalladiumHCID 2794776Tert-butyl 4-(4-nitrophenoxy)piperidine-1-carboxylate

Product 1

HCID 22181157tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-ad3461a930f446419911f2cbea1ac661
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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