反应详情

温度

50 °C

To a solution of 5-bromo-2-bromomethyl-benzoic acid methyl ester (1.00 g, 3.25 mmol) in THF (6.5 mL) was a solution of methylamine in THF (2M, 8.12 mL, 16.24 mmol). The reaction mixture was heated at 50° C. for 4 hours and then concentrated under vacuum. The residue was taken up in EtOAc and the organic layer was then washed with an aqueous 1M HCl solution, brine, dried (Na2SO4), filtered, concentrated under vacuum to give the title compound (0.73 g, 100%) as a yellow solid.

1. concentrationconcentrated under vacuum
2. washthe organic layer was then washed with an aqueous 1M HCl solution, brine
3. dry with materialdried (Na2SO4)
4. filtrationfiltered
5. concentrationconcentrated under vacuum