Tetrahydrofuran → 8-Benzyl-3-(trifluoromethylsulfonyloxy)-8-azabicyclo[3.2.1]oct-3-ene

HRID 820586Notes

Reaction equation

HRID 820586 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH:9]2[CH2:10][C:11](=[O:16])[CH2:12][CH:13]1[CH2:14][CH2:15]2.[CH3:17][SiH:18]([CH3:19])[N:20]([CH3:21])[Si:22]([CH3:23])([CH3:24])[CH3:25].[Na:26].[O:41]1[CH2:42][CH2:43][CH2:44][CH2:45]1.[c:27]1([NH:28][S:34](=[O:35])(=[O:36])[C:37]([F:38])([F:39])[F:40])[cH:29][cH:30][cH:31][cH:32][cH:33]1>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH:9]2[CH2:10][C:11]([O:16][S:34](=[O:35])(=[O:36])[C:37]([F:38])([F:39])[F:40])=[CH:12][CH:13]1[CH2:14][CH2:15]2

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 680121,1,1-Trifluoro-N-phenylmethanesulfonamideHCID 1198468-Benzyl-8-azabicyclo(3.2.1)octan-3-oneHCID 589711N-dimethylsilyl-N-trimethylsilylmethanamineHCID 5360545Sodium

Product 1

HCID 498359108-Benzyl-3-(trifluoromethylsulfonyloxy)-8-azabicyclo[3.2.1]oct-3-ene

Sources & evidence

ORD record
ord-c5b0ef6b517e4d30bca5256f84598ab1
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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