Hydrochloric Acid → Hydrochloric Acid

HRID 820773Notes

Reaction equation

HRID 820773 reaction equation
[CH3:14][O:15][c:16]1[c:17]([NH2:18])[cH:19][cH:20][c:21]([N:23]2[CH2:24][CH2:25][CH:26]([N:29]3[CH2:30][CH2:31][N:32]([CH3:35])[CH2:33][CH2:34]3)[CH2:27][CH2:28]2)[cH:22]1.[Cl:36][c:37]1[n:38][cH:39][c:40]([Cl:53])[c:41](-[c:43]2[cH:44][n:45]([CH3:52])[c:46]3[cH:47][cH:48][cH:49][cH:50][c:51]23)[n:42]1.[ClH:7].[O:8]1[CH2:9][CH2:10][O:11][CH2:12][CH2:13]1.[OH:1][CH2:2][C:3]([F:4])([F:5])[F:6]>>[CH3:14][O:15][c:16]1[c:17]([NH:18][c:37]2[n:38][cH:39][c:40]([Cl:53])[c:41](-[c:43]3[cH:44][n:45]([CH3:52])[c:46]4[cH:47][cH:48][cH:49][cH:50][c:51]34)[n:42]2)[cH:19][cH:20][c:21]([N:23]2[CH2:24][CH2:25][CH:26]([N:29]3[CH2:30][CH2:31][N:32]([CH3:35])[CH2:33][CH2:34]3)[CH2:27][CH2:28]2)[cH:22]1.[ClH:36]

Participants

7

Reactant 5

HCID 313Hydrochloric AcidHCID 64092,2,2-TrifluoroethanolHCID 312751,4-DioxaneHCID 457899912-Methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)anilineHCID 580714413-(2,5-Dichloropyrimidin-4-yl)-1-methyl-1H-indole

Product 2

HCID 313Hydrochloric AcidHCID 580714685-chloro-N-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-4-(1-methylindol-3-yl)pyrimidin-2-amine

Sources & evidence

ORD record
ord-c4da3c42ba47477eb56b7cf09f43e0d6
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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