反应详情

10% Hydrochloric acid in 1,4-dioxane (0.2 mL) was added to N-(5-{7-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl}-pyridin-3-yl)-2-(3-trifluoromethyl-phenyl)-acetamide (Preparation 105, 59 mg, 0.098 mmol) in THF (2 mL) and the mixture was stirred at room temperature for 18 hours. The mixture was evaporated in vacuo and triturated with ether-pentane to afford the title compound as an off white solid in 86% yield, 41 mg.

1. customThe mixture was evaporated in vacuo
2. customtriturated with ether-pentane