反应详情

温度

0 °C

To a suspension of 6-methyl-pyridine-2-carboxylic acid (10 g, 72.9 mmol) in methylene chloride (200 mL) cooled to 0° C. is added methanol (10 mL), 4-dimethylaminopyridine (11.6 g, 94.8 mmol), and EDC (18.2 g, 94.8 mmol). The mixture is stirred at room temperature for 6 h, washed with water and brine, and dried over sodium sulfate. The mixture is filtered and concentrated in vacuo. The residue is chromatographed on SiO2 (50% ethyl acetate/hexanes) to yield the title compound, 9.66 g (92%), as a colorless liquid.

1. washwashed with water and brine
2. dry with materialdried over sodium sulfate
3. filtrationThe mixture is filtered
4. concentrationconcentrated in vacuo
5. customThe residue is chromatographed on SiO2 (50% ethyl acetate/hexanes)