Dimethylformamide → N-(2-tert-butyl-4-cyano-1H-indol-5-yl)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamide

HRID 821245Notes

Reaction equation

HRID 821245 reaction equation
[CH3:34][CH2:35][N:36]([CH2:37][CH3:38])[CH2:39][CH3:40].[F:1][C:2]1([F:17])[O:3][c:4]2[c:5]([cH:7][cH:8][c:9]([C:11]3([C:14](=[O:15])[Cl:16])[CH2:12][CH2:13]3)[cH:10]2)[O:6]1.[NH2:18][c:19]1[c:20]([C:32]#[N:33])[c:21]2[cH:22][c:23]([C:28]([CH3:29])([CH3:30])[CH3:31])[nH:24][c:25]2[cH:26][cH:27]1.[O:41]=[CH:42][N:43]([CH3:44])[CH3:45]>>[F:1][C:2]1([F:17])[O:3][c:4]2[c:5]([cH:7][cH:8][c:9]([C:11]3([C:14](=[O:15])[NH:18][c:19]4[c:20]([C:32]#[N:33])[c:21]5[cH:22][c:23]([C:28]([CH3:29])([CH3:30])[CH3:31])[nH:24][c:25]5[cH:26][cH:27]4)[CH2:12][CH2:13]3)[cH:10]2)[O:6]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 575168501-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropanecarbonyl chlorideHCID 591295115-amino-2-tert-butyl-1H-indole-4-carbonitrile

Product 1

HCID 46199866N-(2-tert-butyl-4-cyano-1H-indol-5-yl)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamide

Sources & evidence

ORD record
ord-e6ad084a5fa54716a969861ea367a555
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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