Pyridine → 4-(4-Iodo-phenyl)-1-methyl-piperidine-4-carboxylic acid (3,5-dichloro-phenyl)-amide

HRID 821634Notes

Reaction equation

HRID 821634 reaction equation
[CH3:44][N:45]([c:46]1[cH:47][cH:48][n:49][cH:50][cH:51]1)[CH3:52].[Cl:24][c:25]1[cH:26][c:27]([NH:32][c:33]2[cH:34][cH:35][cH:36][cH:37][cH:38]2)[cH:28][c:29]([Cl:31])[cH:30]1.[I:7][c:8]1[cH:9][cH:10][c:11]([C:14]2([C:21](=[O:22])[OH:23])[CH2:15][CH2:16][N:17]([CH3:20])[CH2:18][CH2:19]2)[cH:12][cH:13]1.[O:39]=[CH:40][N:41]([CH3:42])[CH3:43].[n:1]1[cH:2][cH:3][cH:4][cH:5][cH:6]1>>[I:7][c:8]1[cH:9][cH:10][c:11]([C:14]2([C:21](=[O:23])[NH:32][c:27]3[cH:26][c:25]([Cl:24])[cH:30][c:29]([Cl:31])[cH:28]3)[CH2:15][CH2:16][N:17]([CH3:20])[CH2:18][CH2:19]2)[cH:12][cH:13]1

Participants

6

Reactant 5

HCID 1049PyridineHCID 6228DimethylformamideHCID 142844-(Dimethylamino)pyridineHCID 190041313,5-Dichloro-N-phenylanilineHCID 224903664-(4-Iodophenyl)-1-methylpiperidine-4-carboxylic acid

Product 1

HCID 865871764-(4-Iodo-phenyl)-1-methyl-piperidine-4-carboxylic acid (3,5-dichloro-phenyl)-amide

Sources & evidence

ORD record
ord-eeafddb88cd94af09d0bc24c2d4e4719
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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