Tetrahydrofuran → (2-methyl-2,3-dihydro-1H-isoindol-5-yl)methanol

HRID 821997Notes

Reaction equation

HRID 821997 reaction equation
[Al+3:2].[C:12]([O:13][C:17](=[O:14])[N:19]1[CH2:20][c:21]2[cH:22][cH:23][c:24]([CH2:28][OH:29])[cH:25][c:26]2[CH2:27]1)([CH3:15])([CH3:16])[CH3:18].[CH2:30]1[O:31][CH2:32][CH2:33][CH2:34]1.[CH2:7]1[O:8][CH2:9][CH2:10][CH2:11]1.[H-:1].[H-:4].[H-:5].[H-:6].[Li+:3]>>[CH3:17][N:19]1[CH2:20][c:21]2[cH:22][cH:23][c:24]([CH2:28][OH:29])[cH:25][c:26]2[CH2:27]1

Participants

6

Reactant 5

HCID 8028Tetrahydrofuran2×HCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 22591344tert-Butyl 5-(hydroxymethyl)-1,3-dihydro-2H-isoindole-2-carboxylate

Product 1

HCID 45088797(2-methyl-2,3-dihydro-1H-isoindol-5-yl)methanol

Sources & evidence

ORD record
ord-8d1b415064ab446b8310dcfa4335a68a
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…