Dimethylformamide → tert-butyl 6-[3-methoxy-1-[(5-methyl-1,2-oxazole-3-carbonyl)amino]-3-oxopropyl]-3,4-dihydro-2H-quinoline-1-carboxylate
Reaction equation
[CH3:1][c:2]1[cH:3][c:4]([C:7](=[O:8])[OH:9])[n:5][o:6]1.[CH3:67][N:68]([CH3:69])[CH:70]=[O:71].[CH:34]([N:35]([CH:36]([CH3:37])[CH3:38])[CH2:39][CH3:40])([CH3:41])[CH3:42].[NH2:43][CH:44]([CH2:45][C:46](=[O:47])[O:48][CH3:49])[c:50]1[cH:51][c:52]2[c:57]([cH:58][cH:59]1)[N:56]([C:60](=[O:61])[O:62][C:63]([CH3:64])([CH3:65])[CH3:66])[CH2:55][CH2:54][CH2:53]2.[P-:10]([F:11])([F:12])([F:13])([F:14])([F:15])[F:16].[n:17]1([O:18][C:19]([N:20]([CH3:21])[CH3:22])=[N+:23]([CH3:24])[CH3:25])[c:26]2[n:27][cH:28][cH:29][cH:30][c:31]2[n:32][n:33]1>>[CH3:1][c:2]1[cH:3][c:4]([C:7](=[O:9])[NH:43][CH:44]([CH2:45][C:46](=[O:47])[O:48][CH3:49])[c:50]2[cH:51][c:52]3[c:57]([cH:58][cH:59]2)[N:56]([C:60](=[O:61])[O:62][C:63]([CH3:64])([CH3:65])[CH3:66])[CH2:55][CH2:54][CH2:53]3)[n:5][o:6]1Participants
7
Reactant 6
HCID 6228Dimethylformamide
HCID 9886Hexafluorophosphate
HCID 769473-Methyl-5-isoxazolecarboxylic acid
HCID 81531Diisopropylethylamine
HCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminium
HCID 23003972Methyl 3-Amino-3-(1-boc-1,2,3,4-tetrahydro-quinolin-6-yl)-propionateProduct 1
Sources & evidence
- ORD record
- ord-659950b2e8924369ac7b0927d08aadef
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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