Ammonium → tert-butyl 3-hydroxy-3-(trifluoroMethyl)azetidine-1-carboxylate

HRID 822553Notes

Reaction equation

HRID 822553 reaction equation
[CH3:22][N+:23]([CH3:24])([CH3:25])[CH3:26].[Cl-:27].[F-:21].[F:13][C:14]([F:15])([F:16])[Si:17]([CH3:18])([CH3:19])[CH3:20].[NH4+:28].[O:1]=[C:2]1[CH2:3][N:4]([C:6](=[O:7])[O:8][C:9]([CH3:10])([CH3:11])[CH3:12])[CH2:5]1.[O:29]1[CH2:30][CH2:31][CH2:32][CH2:33]1>>[OH:1][C:2]1([C:14]([F:13])([F:15])[F:16])[CH2:3][N:4]([C:6](=[O:7])[O:8][C:9]([CH3:10])([CH3:11])[CH3:12])[CH2:5]1

Participants

8

Reactant 7

HCID 223AmmoniumHCID 312ChlorideHCID 6380TetramethylammoniumHCID 8028TetrahydrofuranHCID 28179Fluoride IonHCID 552549(Trifluoromethyl)trimethylsilaneHCID 15194043-Oxo-azetidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 50986409tert-butyl 3-hydroxy-3-(trifluoroMethyl)azetidine-1-carboxylate

Sources & evidence

ORD record
ord-608bf536c78a4849be57c5f49c5c55b3
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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