Dichloromethane → N-(4-(1-hydroxycyclohexyl)benzyl)-2-methyl-1,8-naphthyridine-3-carboxamide

HRID 823072Notes

Reaction equation

HRID 823072 reaction equation
[C:15]([n:16]1[cH:17][cH:18][n:19][cH:20]1)([n:21]1[cH:22][cH:23][n:24][cH:25]1)=[O:26].[CH3:1][c:2]1[n:3][c:4]2[n:5][cH:6][cH:7][cH:8][c:9]2[cH:10][c:11]1[C:12](=[O:13])[OH:14].[CH3:45][CH2:46][O:47][C:48]([CH3:49])=[O:50].[Cl:42][CH2:43][Cl:44].[NH2:27][CH2:28][c:29]1[cH:30][cH:31][c:32]([C:35]2([OH:41])[CH2:36][CH2:37][CH2:38][CH2:39][CH2:40]2)[cH:33][cH:34]1>>[CH3:1][c:2]1[n:3][c:4]2[n:5][cH:6][cH:7][cH:8][c:9]2[cH:10][c:11]1[C:12](=[O:14])[NH:27][CH2:28][c:29]1[cH:30][cH:31][c:32]([C:35]2([OH:41])[CH2:36][CH2:37][CH2:38][CH2:39][CH2:40]2)[cH:33][cH:34]1

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 8857Ethyl AcetateHCID 682631,1'-CarbonyldiimidazoleHCID 27369082-methyl-1,8-naphthyridine-3-carboxylic acidHCID 666332311-(4-(Aminomethyl)phenyl)cyclohexanol

Product 1

HCID 46908389N-(4-(1-hydroxycyclohexyl)benzyl)-2-methyl-1,8-naphthyridine-3-carboxamide

Sources & evidence

ORD record
ord-d30d4daef99a4a0082f8df41bd43cf50
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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