Dimethylformamide → 5-(4-chloro-3-(1-(pyridin-2-yl)cyclopropyl carbamoyl)phenyl)-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide
Reaction equation
[CH3:70][CH2:71][O:72][C:73](=[O:74])[CH3:75].[Cl:1][c:2]1[c:3]([C:4](=[O:5])[OH:6])[cH:7][c:8](-[c:11]2[cH:12][cH:13][c:14]3[c:15]([c:16]([C:26]([NH:27][CH3:28])=[O:29])[c:17](-[c:19]4[cH:20][cH:21][c:22]([F:25])[cH:23][cH:24]4)[o:18]3)[cH:30]2)[cH:9][cH:10]1.[O:41]=[CH:42][N:43]([CH3:44])[CH3:45].[P-:46]([F:47])([F:48])([F:49])([F:50])([F:51])[F:52].[n:31]1[c:32]([C:37]2([NH2:40])[CH2:38][CH2:39]2)[cH:33][cH:34][cH:35][cH:36]1.[n:53]1([O:54][C:55]([N:56]([CH3:57])[CH3:58])=[N+:59]([CH3:60])[CH3:61])[c:62]2[n:63][cH:64][cH:65][cH:66][c:67]2[n:68][n:69]1>>[Cl:1][c:2]1[c:3]([C:4](=[O:5])[NH:40][C:37]2([c:32]3[n:31][cH:36][cH:35][cH:34][cH:33]3)[CH2:38][CH2:39]2)[cH:7][c:8](-[c:11]2[cH:12][cH:13][c:14]3[c:15]([c:16]([C:26]([NH:27][CH3:28])=[O:29])[c:17](-[c:19]4[cH:20][cH:21][c:22]([F:25])[cH:23][cH:24]4)[o:18]3)[cH:30]2)[cH:9][cH:10]1Participants
7
Reactant 6
HCID 6228Dimethylformamide
HCID 8857Ethyl Acetate
HCID 9886Hexafluorophosphate
HCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminium
HCID 111054091-(Pyridin-2-yl)cyclopropanamine
HCID 592751302-Chloro-5-(2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-5-yl)benzoic acidProduct 1
Sources & evidence
- ORD record
- ord-56dbac8185034ac6a66e6aa78c1a5359
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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