Acetic Acid → 5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-7-[(3-methylpiperazin-1-yl)methyl]-3,4-dihydroquinazolin-2(1H)-one

HRID 824142Notes

Reaction equation

HRID 824142 reaction equation
[BrH:45].[C:46]([OH:47])(=[O:48])[CH3:49].[CH2:50]([Cl:51])[Cl:52].[Cl:1][c:2]1[c:3](-[c:8]2[c:9]3[c:14]([cH:15][c:16]([CH2:18][N:19]4[CH2:20][CH:21]([CH3:35])[N:22]([C:25]([O:26][CH2:27][c:28]5[cH:29][cH:30][cH:31][cH:32][cH:33]5)=[O:34])[CH2:23][CH2:24]4)[cH:17]2)[N:13]([c:36]2[c:37]([Cl:43])[cH:38][cH:39][cH:40][c:41]2[Cl:42])[C:12](=[O:44])[NH:11][CH2:10]3)[cH:4][cH:5][cH:6][cH:7]1>>[Cl:1][c:2]1[c:3](-[c:8]2[c:9]3[c:14]([cH:15][c:16]([CH2:18][N:19]4[CH2:20][CH:21]([CH3:35])[NH:22][CH2:23][CH2:24]4)[cH:17]2)[N:13]([c:36]2[c:37]([Cl:43])[cH:38][cH:39][cH:40][c:41]2[Cl:42])[C:12](=[O:44])[NH:11][CH2:10]3)[cH:4][cH:5][cH:6][cH:7]1

Participants

5

Reactant 4

HCID 176Acetic AcidHCID 260Hydrogen BromideHCID 6344DichloromethaneHCID 22647930Benzyl 4-{[5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-2-oxo-1,2,3,4-tetrahydroquinazolin-7-yl]methyl}-2-methylpiperazine-1-carboxylate

Product 1

HCID 101861125-(2-chlorophenyl)-1-(2,6-dichlorophenyl)-7-[(3-methylpiperazin-1-yl)methyl]-3,4-dihydroquinazolin-2(1H)-one

Sources & evidence

ORD record
ord-927a70bc4f53452da525e423972e6032
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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