Hydrochloric Acid → 2-[3-(3-Fluoro-azetidin-1-yl)-phenyl]-3,3-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carboxylic acid
Reaction equation
[Br:1][c:2]1[cH:3][c:4]([CH:8]2[NH:9][c:10]3[cH:11][cH:12][c:13]([C:20](=[O:21])[OH:22])[cH:14][c:15]3[CH2:16][C:17]2([CH3:18])[CH3:19])[cH:5][cH:6][cH:7]1.[C:36](=[O:37])([O-:38])[O-:39].[CH3:29][N:30]([CH3:31])[CH2:32][C:33]([OH:34])=[O:35].[CH3:42][S:43](=[O:44])[CH3:45].[ClH:28].[Cu:46][I:47].[F:23][CH:24]1[CH2:25][NH:26][CH2:27]1.[K+:40].[K+:41]>>[c:2]1([N:26]2[CH2:25][CH:24]([F:23])[CH2:27]2)[cH:3][c:4]([CH:8]2[NH:9][c:10]3[cH:11][cH:12][c:13]([C:20](=[O:21])[OH:22])[cH:14][c:15]3[CH2:16][C:17]2([CH3:18])[CH3:19])[cH:5][cH:6][cH:7]1Participants
9
Reactant 8
HCID 313Hydrochloric Acid
HCID 673N,N-Dimethylglycine
HCID 679Dimethyl Sulfoxide
HCID 813Potassium Cation2×
HCID 19660Carbonate Ion
HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)
HCID 36035423-Fluoroazetidine
HCID 584761942-(3-Bromophenyl)-3,3-dimethyl-1,2,3,4-tetrahydroquinoline-6-carboxylic acidProduct 1
Sources & evidence
- ORD record
- ord-c8dcaeea897049e584226b112607f95f
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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