Hydrochloric Acid → 2-[(6-{[4-(Aminomethyl)-1H-1,2,3-triazol-1-yl]methyl}pyridin-2-yl)amino]-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

HRID 824625Notes

Reaction equation

HRID 824625 reaction equation
[C:1]([N:5]([C:2](=[O:3])[O-:4])[CH2:9][c:10]1[n:11][n:12][n:13]([CH2:15][c:16]2[n:17][c:18]([NH:22][c:23]3[s:24][c:25](-[c:31]4[c:32]([F:42])[cH:33][c:34]([C:38]([CH3:39])([CH3:40])[OH:41])[cH:35][c:36]4[F:37])[cH:26][c:27]3[C:28](=[O:29])[NH2:30])[cH:19][cH:20][cH:21]2)[cH:14]1)([CH3:6])([CH3:7])[CH3:8].[CH3:50][CH2:51][O:52][C:53]([CH3:54])=[O:55].[ClH:43].[O:44]1[CH2:45][CH2:46][O:47][CH2:48][CH2:49]1>>[NH2:5][CH2:9][c:10]1[n:11][n:12][n:13]([CH2:15][c:16]2[n:17][c:18]([NH:22][c:23]3[s:24][c:25](-[c:31]4[c:32]([F:42])[cH:33][c:34]([C:38]([CH3:39])([CH3:40])[OH:41])[cH:35][c:36]4[F:37])[cH:26][c:27]3[C:28](=[O:29])[NH2:30])[cH:19][cH:20][cH:21]2)[cH:14]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 312751,4-DioxaneHCID 178458578N-tert-butyl-N-[[1-[[6-[[3-carbamoyl-5-[2,6-difluoro-4-(2-hydroxypropan-2-yl)phenyl]thiophen-2-yl]amino]-2-pyridinyl]methyl]triazol-4-yl]methyl]carbamate

Product 1

HCID 595256362-[(6-{[4-(Aminomethyl)-1H-1,2,3-triazol-1-yl]methyl}pyridin-2-yl)amino]-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Sources & evidence

ORD record
ord-3e5f7cd80b3c4e938bfcdcdab318aef6
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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