反应详情

温度

25 °C

To a solution of 3-methyl-2-[pyridine-3-carbonyl]-amino-butyric acid methyl ester (1.5 g, 6.3 mmol), in methanol (15 mL), THF (9 mL) was added LiOH (1.3 g, 31.7 mmol) dissolved in water (3 mL). The mixture was allowed to stir at room temperature (25° C.) over 2 h. Solvent was evaporated from reaction mixture, dissolved in water (15 mL), acidified with 1.5N HCl extracted with ethyl acetate (150 mL), dried over sodium sulphate and concentrated to obtain product as yellow colour solid (1.38 g, 99%).

1. customSolvent was evaporated from reaction mixture
2. dissolutiondissolved in water (15 mL)
3. extractionextracted with ethyl acetate (150 mL)
4. dry with materialdried over sodium sulphate
5. concentrationconcentrated