Methane → Diethyl (4-amino-3-fluorophenyl)methylmalonate

HRID 824988Notes

Reaction equation

HRID 824988 reaction equation
[C:31].[CH3:25][CH2:26][O:27][C:28](=[O:29])[CH3:30].[F:1][c:2]1[cH:3][c:4]([C:11]([C:12](=[O:13])[O:14][CH2:15][CH3:16])([C:17](=[O:18])[O:19][CH2:20][CH3:21])[CH3:22])[cH:5][cH:6][c:7]1[N+:8]([O-:9])=[O:10].[H:23][H:24].[Pd:32]>>[F:1][c:2]1[cH:3][c:4]([C:11]([C:12](=[O:13])[O:14][CH2:15][CH3:16])([C:17](=[O:18])[O:19][CH2:20][CH3:21])[CH3:22])[cH:5][cH:6][c:7]1[NH2:8]

Participants

6

Reactant 5

HCID 297MethaneHCID 8857Ethyl AcetateHCID 23938PalladiumHCID 42638641,3-Diethyl 2-(3-fluoro-4-nitrophenyl)-2-methylpropanedioateHCID 178418361HCID 178418361, compound

Product 1

HCID 11630571Diethyl (4-amino-3-fluorophenyl)methylmalonate

Sources & evidence

ORD record
ord-0258e4636d584779ad6f11b86c38aa87
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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