1,1'-Carbonyldiimidazole → HCID 58577331, compound

HRID 82508Notes

Reaction equation

HRID 82508 reaction equation
[N:1]1([C:13]2[CH:18]=[CH:17][C:16]([NH:19][C:20]3[C:25]([NH2:26])=[CH:24][CH:23]=[CH:22][N:21]=3)=[CH:15][CH:14]=2)[C:5]2=[N:6][C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[N:4]2[CH2:3][CH2:2]1.[C:27](N1C=CN=C1)(N1C=CN=C1)=[O:28]>C1COCC1>[N:1]1([C:13]2[CH:14]=[CH:15][C:16]([N:19]3[C:20]4=[N:21][CH:22]=[CH:23][CH:24]=[C:25]4[NH:26][C:27]3=[O:28])=[CH:17][CH:18]=2)[C:5]2=[N:6][C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[N:4]2[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 682631,1'-CarbonyldiimidazoleHCID 58577334HCID 58577334, compound

Product 1

HCID 58577331HCID 58577331, compoundYield 55.8%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of N2-[4-(2,3-dihydro-1H-imidazo[1,2-a]benzimidazol-1-yl)phenyl]pyridine-2,3-diamine (20 mg) and 1,1′-carbonyldiimidazole (19 mg) in THF (5 mL) was stirred at ambient temperature overnight. After this time, the solids that formed were collected by filtration to afford 3-[4-(2,3-dihydro-1H-imidazo[1,2-a]benzimidazol-1-yl)phenyl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one (12 mg) as off-white crystals.

Workup

  1. customAfter this time, the solids that formed
  2. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-3ab564c7755848a39fbef5dba18d1c9a
Source dataset
uspto-grants-2014_09
Patent number
US08846713B2

Reaction notes

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