Acetic Acid → para-methyl 4-Anilino-1-Boc-piperidine

HRID 825257Notes

Reaction equation

HRID 825257 reaction equation
[C:23]([O:24][BH-:25]([O:26][C:27](=[O:28])[CH3:29])[O:30][C:31](=[O:32])[CH3:33])(=[O:34])[CH3:35].[C:37](=[O:38])([OH:39])[O-:40].[CH3:15][c:16]1[cH:17][cH:18][c:19]([NH2:20])[cH:21][cH:22]1.[CH3:47][C:48](=[O:49])[OH:50].[Na+:36].[Na+:41].[O:1]=[C:2]1[CH2:3][CH2:4][N:5]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:6][CH2:7]1.[O:42]1[CH2:43][CH2:44][CH2:45][CH2:46]1>>[CH:2]1([NH:20][c:19]2[cH:18][cH:17][c:16]([CH3:15])[cH:22][cH:21]2)[CH2:3][CH2:4][N:5]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:6][CH2:7]1

Participants

8

Reactant 7

HCID 176Acetic AcidHCID 769Bicarbonate IonHCID 923Sodium ion2×HCID 7813p-ToluidineHCID 8028TetrahydrofuranHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 2724942Triacetoxyborohydride

Product 1

HCID 22557837para-methyl 4-Anilino-1-Boc-piperidine

Sources & evidence

ORD record
ord-580018b69cdd41269753802440d44144
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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