1,2-Dichloroethane → tert-Butyl 4-(2-hydroxyanilino)piperidine-1-carboxylate

HRID 825620Notes

Reaction equation

HRID 825620 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11](=[O:14])[CH2:12][CH2:13]1.[C:23]([O:24][BH-:25]([O:26][C:27](=[O:28])[CH3:29])[O:30][C:31](=[O:32])[CH3:33])(=[O:34])[CH3:35].[CH3:42][CH2:43][O:44][C:45](=[O:46])[CH3:47].[CH3:48][C:49](=[O:50])[OH:51].[Cl:52][CH2:53][CH2:54][Cl:55].[NH2:15][c:16]1[cH:17][cH:18][cH:19][cH:20][c:21]1[OH:22].[Na+:36].[Na+:41].[O-:37][C:38]([OH:39])=[O:40]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([NH:15][c:16]2[cH:17][cH:18][cH:19][cH:20][c:21]2[OH:22])[CH2:12][CH2:13]1

Participants

9

Reactant 8

HCID 111,2-DichloroethaneHCID 176Acetic AcidHCID 769Bicarbonate IonHCID 923Sodium ion2×HCID 58012-AminophenolHCID 8857Ethyl AcetateHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 2724942Triacetoxyborohydride

Product 1

HCID 22380697tert-Butyl 4-(2-hydroxyanilino)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-962a9427ee8b4b17aebac107b997f3e1
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…