反应详情

A solution of N2-methylpyridine-2,3-diamine (7 g) and CDI (13.82 g) in THF (100 mL) was refluxed for 5 h. The reaction mixture was concentrated in vacuo. The residue was purified by column chromatography (NH silica gel, eluted with 0%-100% EtOAc in hexane) to give 3-methyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one (7 g) as a light brown solid.

1. concentrationThe reaction mixture was concentrated in vacuo
2. customThe residue was purified by column chromatography (NH silica gel, eluted with 0%-100% EtOAc in hexane)