Diisopropylethylamine → HCID 178509315, 화합물

HRID 82719노트

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HRID 82719 반응식
[NH2:1][C:2]1[C:3]([C:7](SC)=[N:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[C:11]([Br:16])[CH:10]=2)=[N:4][S:5][N:6]=1.Cl.[NH2:20][OH:21].C(N(CC)C(C)C)(C)C>C(O)C>[NH2:1][C:2]1[C:3]([C:7](=[N:20][OH:21])[NH:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[C:11]([Br:16])[CH:10]=2)=[N:4][S:5][N:6]=1

참가 물질

5

반응물 3

HCID 81531DiisopropylethylamineHCID 443297Hydroxyamine hydrochlorideHCID 58558200Methyl 4-amino-N-(3-bromo-4-fluorophenyl)-1,2,5-thiadiazole-3-carbimidothioate

생성물 1

HCID 178509315HCID 178509315, 화합물수율 79.4%

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
90 °C

실험 절차

A solution of methyl 4-amino-N-(3-bromo-4-fluorophenyl)-1,2,5-thiadiazole-3-carbimidothioate (78 mg, 0.22 mmol) in ethanol (2.3 mL) was treated with hydroxylamine hydrochloride (62 mg, 0.9 mmol) followed by N,N-diisopropylethylamine (180 μL, 1.0 mmol) and stirred at 90° C. for 16 h. The reaction mixture was purified by preparative HPLC to give the desired product (58 mg, 78%). LCMS for C9H8BrFN5OS (M+H)+: m/z=331.9, 333.9.

후처리

  1. customThe reaction mixture was purified by preparative HPLC

출처 및 근거

ORD 기록
ord-ee9e87a8184247e6af32998e2fa6b447
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846726B2

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