Hydrochloric Acid → Hydrochloric Acid

HRID 827236Notes

Reaction equation

HRID 827236 reaction equation
[CH3:52][OH:53].[CH3:55][CH2:56][O:57][C:58](=[O:59])[CH3:60].[ClH:54].[NH2:1][c:2]1[n:3][cH:4][cH:5][cH:6][c:7]1-[c:8]1[n:9][c:10]2[c:11]([n:12][c:13](-[c:16]3[cH:17][c:18]([N:22]4[CH2:23][CH2:24][CH:25]([C:28]([N:29]([CH3:30])[CH3:31])=[O:32])[CH2:26][CH2:27]4)[cH:19][cH:20][cH:21]3)[cH:14][cH:15]2)[n:33]1-[c:34]1[cH:35][cH:36][c:37]([C:40]2([NH:44][C:45](=[O:46])[O:47][C:48]([CH3:49])([CH3:50])[CH3:51])[CH2:41][CH2:42][CH2:43]2)[cH:38][cH:39]1>>[ClH:54].[NH2:1][c:2]1[n:3][cH:4][cH:5][cH:6][c:7]1-[c:8]1[n:9][c:10]2[c:11]([n:12][c:13](-[c:16]3[cH:17][c:18]([N:22]4[CH2:23][CH2:24][CH:25]([C:28]([N:29]([CH3:30])[CH3:31])=[O:32])[CH2:26][CH2:27]4)[cH:19][cH:20][cH:21]3)[cH:14][cH:15]2)[n:33]1-[c:34]1[cH:35][cH:36][c:37]([C:40]2([NH2:44])[CH2:41][CH2:42][CH2:43]2)[cH:38][cH:39]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 8857Ethyl AcetateHCID 71142509tert-butyl (1-{4-[2-(2-aminopyridin-3-yl)-5-{3-[4-(dimethylcarbamoyl)piperidin-1-yl]phenyl}-3H-imidazo[4,5-b]pyridin-3-yl]phenyl}cyclobutyl)carbamate

Product 2

HCID 313Hydrochloric AcidHCID 711384271-[3-[3-[4-(1-aminocyclobutyl)phenyl]-2-(2-amino-3-pyridinyl)imidazo[4,5-b]pyridin-5-yl]phenyl]-N,N-dimethylpiperidine-4-carboxamide

Sources & evidence

ORD record
ord-f270a131e31e461c9d45f557848a5deb
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…