4-Aminophenol → [4-(4-Amino-phenoxy)-pyridin-2-yl]pyrrolidin-1-yl-methanone

HRID 827397Notes

Reaction equation

HRID 827397 reaction equation
[Cl:9][c:10]1[cH:11][c:12]([C:16](=[O:17])[N:18]2[CH2:19][CH2:20][CH2:21][CH2:22]2)[n:13][cH:14][cH:15]1.[K+:23].[K+:24].[NH2:1][c:2]1[cH:3][cH:4][c:5]([OH:6])[cH:7][cH:8]1.[O-:25][C:26]([O-:27])=[O:28].[O:29]=[CH:30][N:31]([CH3:32])[CH3:33]>>[NH2:1][c:2]1[cH:3][cH:4][c:5]([O:6][c:10]2[cH:11][c:12]([C:16](=[O:17])[N:18]3[CH2:19][CH2:20][CH2:21][CH2:22]3)[n:13][cH:14][cH:15]2)[cH:7][cH:8]1

Participants

6

Reactant 5

HCID 4034-AminophenolHCID 813Potassium Cation2×HCID 6228DimethylformamideHCID 19660Carbonate IonHCID 106799924-Chloro-2-(pyrrolidine-1-carbonyl)pyridine

Product 1

HCID 59134565[4-(4-Amino-phenoxy)-pyridin-2-yl]pyrrolidin-1-yl-methanone

Sources & evidence

ORD record
ord-fc2c5419a74a451e8fa4aa48a2a2b6bd
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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