Tetrahydrofuran → (2-Chloro-6-trifluoromethylpyrimidin-4-yl)-methyl-(4-trifluoromethoxyphenyl)-amine

HRID 827887Notes

Reaction equation

HRID 827887 reaction equation
[CH2:35]1[O:36][CH2:37][CH2:38][CH2:39]1.[CH3:13][NH:14][c:15]1[cH:16][cH:17][c:18]([O:21][C:22]([F:23])([F:24])[F:25])[cH:19][cH:20]1.[CH:26]([N:27]([CH:28]([CH3:29])[CH3:30])[CH2:31][CH3:32])([CH3:33])[CH3:34].[Cl:1][c:2]1[n:3][c:4]([C:9]([F:10])([F:11])[F:12])[cH:5][c:6]([Cl:8])[n:7]1>>[Cl:1][c:2]1[n:3][c:4]([C:9]([F:10])([F:11])[F:12])[cH:5][c:6]([N:14]([CH3:13])[c:15]2[cH:16][cH:17][c:18]([O:21][C:22]([F:23])([F:24])[F:25])[cH:19][cH:20]2)[n:7]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 81531DiisopropylethylamineHCID 3342032,4-Dichloro-6-(trifluoromethyl)pyrimidineHCID 737351n-Methyl-4-(trifluoromethoxy)aniline

Product 1

HCID 57507179(2-Chloro-6-trifluoromethylpyrimidin-4-yl)-methyl-(4-trifluoromethoxyphenyl)-amine

Sources & evidence

ORD record
ord-c00b4c0ef09a4d40833b242e1bd2901f
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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