Methylamine → p38alpha Inhibitor 2

HRID 828090Notes

Reaction equation

HRID 828090 reaction equation
[CH3:35][NH2:36].[CH3:43][CH2:44][O:45][C:46](=[O:47])[CH3:48].[Cl:1][CH2:2][CH2:3][O:4][c:5]1[c:6]([C:11]([CH3:12])([CH3:13])[NH:14][c:15]2[c:16](=[O:34])[n:17](-[c:21]3[cH:22][c:23]([C:24](=[O:25])[NH:26][CH:27]4[CH2:28][CH2:29]4)[cH:30][cH:31][c:32]3[CH3:33])[cH:18][cH:19][n:20]2)[cH:7][cH:8][cH:9][cH:10]1.[O:37]1[CH2:38][CH2:39][O:40][CH2:41][CH2:42]1>>[CH2:2]([CH2:3][O:4][c:5]1[c:6]([C:11]([CH3:12])([CH3:13])[NH:14][c:15]2[c:16](=[O:34])[n:17](-[c:21]3[cH:22][c:23]([C:24](=[O:25])[NH:26][CH:27]4[CH2:28][CH2:29]4)[cH:30][cH:31][c:32]3[CH3:33])[cH:18][cH:19][n:20]2)[cH:7][cH:8][cH:9][cH:10]1)[NH:36][CH3:35]

Participants

5

Reactant 4

HCID 6329MethylamineHCID 8857Ethyl AcetateHCID 312751,4-DioxaneHCID 666886643-[3-[[1-[2-(2-Chloroethoxy)phenyl]-1-methylethyl]amino]-2-oxo-1(2H)-pyrazinyl]-N-cyclopropyl-4-methyl-benzamide

Product 1

HCID 25145735p38alpha Inhibitor 2

Sources & evidence

ORD record
ord-286f4428065f4ccda225f04b56af737d
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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