反应详情

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), sodium (1.32 g, 57.42 mmol) was added portionwise to MeOH (145 mL). Methyl 2-(acetoxymethyl)oxazole-4-carboxylate (23.30 g, 116.99 mmol) was then added and the reaction mixture was stirred for 1 h at rt. Sat. aq. NH4Cl (760 mL) was then added and the mixture was extracted with EA (2×760 mL). The combined org. layers were dried over MgSO4, filtered, and the solvents were removed under reduced pressure to give the title compound as a white solid: TLC: rf (1:9 hept-EA)=0.33. LC-MS-conditions 06: tR=0.31 min, [M+H]+=158.15.

1. extractionthe mixture was extracted with EA (2×760 mL)
2. dry with materiallayers were dried over MgSO4
3. filtrationfiltered
4. customthe solvents were removed under reduced pressure