Dimethyl Sulfoxide → N-[5-[[4-(hydroxymethyl)-3-(trifluoromethyl)pyrazol-1-yl]methyl]-2,3-dihydro-1H-inden-2-yl]furan-2-sulfonamide

HRID 828767Notes

Reaction equation

HRID 828767 reaction equation
[CH2:39]1[O:40][CH2:41][CH2:42][CH2:43]1.[CH3:23][CH2:24][N:25]([CH2:26][CH3:27])[CH2:28][CH3:29].[CH3:44][S:45]([CH3:46])=[O:47].[NH2:1][CH:2]1[CH2:3][c:4]2[cH:5][cH:6][c:7]([CH2:11][n:12]3[n:13][c:14]([C:19]([F:20])([F:21])[F:22])[c:15]([CH2:17][OH:18])[cH:16]3)[cH:8][c:9]2[CH2:10]1.[o:30]1[c:31]([S:35](=[O:36])(=[O:37])[Cl:38])[cH:32][cH:33][cH:34]1>>[NH:1]([CH:2]1[CH2:3][c:4]2[cH:5][cH:6][c:7]([CH2:11][n:12]3[n:13][c:14]([C:19]([F:20])([F:21])[F:22])[c:15]([CH2:17][OH:18])[cH:16]3)[cH:8][c:9]2[CH2:10]1)[S:35]([c:31]1[o:30][cH:34][cH:33][cH:32]1)(=[O:36])=[O:37]

Participants

6

Reactant 5

HCID 679Dimethyl SulfoxideHCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 2795072Furan-2-sulfonyl ChlorideHCID 67088047[1-[(2-amino-2,3-dihydro-1H-inden-5-yl)methyl]-3-(trifluoromethyl)pyrazol-4-yl]methanol

Product 1

HCID 67088097N-[5-[[4-(hydroxymethyl)-3-(trifluoromethyl)pyrazol-1-yl]methyl]-2,3-dihydro-1H-inden-2-yl]furan-2-sulfonamide

Sources & evidence

ORD record
ord-e7cce9950807407c8e33d5987ec67ac7
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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