Dichloromethane → 1-Amino-6-(4-fluorophenyl)piperidin-2-one

HRID 828841Notes

Reaction equation

HRID 828841 reaction equation
[CH3:33][CH2:34][O:35][C:36]([CH3:37])=[O:38].[Cl:30][CH2:31][Cl:32].[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[N:9]([NH:15][C:16](=[O:17])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22])[C:10](=[O:14])[CH2:11][CH2:12][CH2:13]2)[cH:6][cH:7]1.[F:23][C:24]([F:25])([F:26])[C:27]([OH:28])=[O:29]>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[N:9]([NH2:15])[C:10](=[O:14])[CH2:11][CH2:12][CH2:13]2)[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 8857Ethyl AcetateHCID 66859411Tert-butyl 2-(4-fluorophenyl)-6-oxopiperidin-1-ylcarbamate

Product 1

HCID 581101281-Amino-6-(4-fluorophenyl)piperidin-2-one

Sources & evidence

ORD record
ord-4b01fd21c9364d69b36c8b38cd845449
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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