Dimethylformamide → 4-[4-(7-Bromo-pyrrolo[2,1-f][1,2,4]-triazin-2ylamino)-phenyl]-piperidine-1-carboxylic acid tert butyl ester

HRID 828902Notes

Reaction equation

HRID 828902 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]2[cH:6][n:7][c:8]([OH:11])[n:9][n:10]12.[C:26]([CH3:27])([CH3:28])([CH3:29])[O:30][C:31](=[O:32])[N:33]1[CH2:34][CH2:35][CH:36]([c:39]2[cH:40][cH:41][c:42]([NH2:45])[cH:43][cH:44]2)[CH2:37][CH2:38]1.[CH:12]([N:13]([CH2:14][CH3:15])[CH:16]([CH3:17])[CH3:18])([CH3:19])[CH3:20].[O:21]=[CH:22][N:23]([CH3:24])[CH3:25]>>[Br:1][c:2]1[cH:3][cH:4][c:5]2[cH:6][n:7][c:8]([NH:45][c:42]3[cH:41][cH:40][c:39]([CH:36]4[CH2:35][CH2:34][N:33]([C:31]([O:30][C:26]([CH3:27])([CH3:28])[CH3:29])=[O:32])[CH2:38][CH2:37]4)[cH:44][cH:43]3)[n:9][n:10]12

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 81531DiisopropylethylamineHCID 21940085tert-Butyl 4-(4-aminophenyl)piperidine-1-carboxylateHCID 178517419HCID 178517419, compound

Product 1

HCID 866617024-[4-(7-Bromo-pyrrolo[2,1-f][1,2,4]-triazin-2ylamino)-phenyl]-piperidine-1-carboxylic acid tert butyl ester

Sources & evidence

ORD record
ord-13ef899ba9bb402b9afcfc2125157c6c
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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