Hydrochloric Acid → 2-Methoxy-5-(trifluoromethyl)nicotinaldehyde

HRID 830265Notes

Reaction equation

HRID 830265 reaction equation
[Br:1][c:2]1[c:3]([O:12][CH3:13])[n:4][cH:5][c:6]([C:8]([F:9])([F:10])[F:11])[cH:7]1.[CH2:14]([Li:15])[CH2:16][CH2:17][CH3:18].[CH3:19][N:20]([CH:21]=[O:22])[CH3:23].[CH3:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30].[ClH:24]>>[c:2]1([CH:21]=[O:22])[c:3]([O:12][CH3:13])[n:4][cH:5][c:6]([C:8]([F:9])([F:10])[F:11])[cH:7]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 8058HexaneHCID 148370183-Bromo-2-methoxy-5-(trifluoromethyl)pyridineHCID 178418339Butyllithium

Product 1

HCID 230490052-Methoxy-5-(trifluoromethyl)nicotinaldehyde

Sources & evidence

ORD record
ord-c4f7a2c343684806a116c1a59b5bf499
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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