Water → 2-chloro-N-(2-chloro-6-methoxy-5-nitropyrimidin-4-yl)-5-(2,3-difluoro-6-methoxy-benzyloxy)-4-methoxyaniline

HRID 830721Notes

Reaction equation

HRID 830721 reaction equation
[CH3:45][CH2:46][O:47][C:48](=[O:49])[CH3:50].[CH3:51][C:52]#[N:53].[CH:36]([N:37]([CH2:38][CH3:39])[CH:40]([CH3:41])[CH3:42])([CH3:43])[CH3:44].[Cl:14][c:15]1[c:16]([NH2:17])[cH:18][c:19]([O:24][CH2:25][c:26]2[c:27]([F:35])[c:28]([F:34])[cH:29][cH:30][c:31]2[O:32][CH3:33])[c:20]([O:22][CH3:23])[cH:21]1.[Cl:1][c:2]1[n:3][c:4]([O:12][CH3:13])[c:5]([N+:9](=[O:10])[O-:11])[c:6]([Cl:8])[n:7]1.[OH2:54]>>[Cl:1][c:2]1[n:3][c:4]([O:12][CH3:13])[c:5]([N+:9](=[O:10])[O-:11])[c:6]([NH:17][c:16]2[c:15]([Cl:14])[cH:21][c:20]([O:22][CH3:23])[c:19]([O:24][CH2:25][c:26]3[c:27]([F:35])[c:28]([F:34])[cH:29][cH:30][c:31]3[O:32][CH3:33])[cH:18]2)[n:7]1

Participants

7

Reactant 6

HCID 962WaterHCID 6342AcetonitrileHCID 8857Ethyl AcetateHCID 81531DiisopropylethylamineHCID 593096392-Chloro-5-(2,3-difluoro-6-methoxybenzyloxy)-4-methoxyanilineHCID 593099452,4-Dichloro-5-nitro-6-methoxypyrimidine

Product 1

HCID 866412872-chloro-N-(2-chloro-6-methoxy-5-nitropyrimidin-4-yl)-5-(2,3-difluoro-6-methoxy-benzyloxy)-4-methoxyaniline

Sources & evidence

ORD record
ord-696c86ff45e348929005d3fc4ac092b9
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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