Hydrochloric Acid → HCID 44432430, compound

HRID 83094Notes

Reaction equation

HRID 83094 reaction equation
[ClH:1].[OH:2][C:3]1[C:16]2[C:15](=[O:17])[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[O:8][C:7]=2[CH:6]=[C:5]([O:18][CH2:19][CH:20]2[CH2:22][O:21]2)[CH:4]=1>C(OCC)(=O)C>[Cl:1][CH2:22][CH:20]([OH:21])[CH2:19][O:18][C:5]1[CH:4]=[C:3]([OH:2])[C:16]2[C:15](=[O:17])[C:14]3[C:9]([O:8][C:7]=2[CH:6]=1)=[CH:10][CH:11]=[CH:12][CH:13]=3

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 105171431-hydroxy-3-(oxiran-2-ylmethoxy)-9H-xanthen-9-one

Product 1

HCID 44432430HCID 44432430, compoundYield 94.1%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

An aqueous ethyl acetate 1M-HCl (3 mL) was added to 1-hydroxy-3-(oxiran-2-ylmethoxy)-9H-xanthen-9-one (30 mg, 0.11 mmol) prepared in Step 2 of Example 2, followed by stirring at room temperature for 30 minutes, and the reaction solvent was removed under reduced pressure. Ether was added to the residue, followed by sonication, and the solvent was removed to give the title compound (32 mg, 94.1%) as a red solid.

Workup

  1. customthe reaction solvent was removed under reduced pressure
  2. additionEther was added to the residue
  3. customfollowed by sonication
  4. customthe solvent was removed

Sources & evidence

ORD record
ord-00289ee2b21548d6bd299ddc836404e3
Source dataset
uspto-grants-2014_09
Patent number
US08846749B2

Reaction notes

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