Hydrochloric Acid → HCID 46932897, compound

HRID 83101Notes

Reaction equation

HRID 83101 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[C:17]2[C:16](=[O:18])[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[O:9][C:8]=2[CH:7]=[C:6]([O:19][CH2:20][CH:21]2[CH2:23][O:22]2)[CH:5]=1>C(OCC)(=O)C>[Cl:1][CH2:23][CH:21]([OH:22])[CH2:20][O:19][C:6]1[CH:5]=[C:4]([O:3][CH3:2])[C:17]2[C:16](=[O:18])[C:15]3[C:10]([O:9][C:8]=2[CH:7]=1)=[CH:11][CH:12]=[CH:13][CH:14]=3

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 46932895HCID 46932895, compound

Product 1

HCID 46932897HCID 46932897, compoundYield 71.3%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Aqueous ethyl acetate 1M-HCl (3 mL) was added to 1-methoxy-3-(oxiran-2-ylmethoxy)-9H-xanthen-9-one (25 mg, 0.08 mmol) prepared in Step 4 of Example 9, followed by stirring at room temperature for 30 minutes, and the reaction solvent was removed under reduced pressure. Ether was added to the residue, followed by sonication, and the solvent was removed to give the title compound (20 mg, 71.3%) as a reddish brown solid.

Workup

  1. customthe reaction solvent was removed under reduced pressure
  2. additionEther was added to the residue
  3. customfollowed by sonication
  4. customthe solvent was removed

Sources & evidence

ORD record
ord-3a84a42337c34bd087e328fdc23dc92d
Source dataset
uspto-grants-2014_09
Patent number
US08846749B2

Reaction notes

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