Hydrochloric Acid → HCID 51038186, compound

HRID 83103Notes

Reaction equation

HRID 83103 reaction equation
[ClH:1].[OH:2][C:3]1[C:16]2[C:15](=[O:17])[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[S:8][C:7]=2[CH:6]=[C:5]([O:18][CH2:19][CH:20]2[CH2:22][S:21]2)[CH:4]=1>C(OCC)(=O)C>[Cl:1][CH2:22][CH:20]([SH:21])[CH2:19][O:18][C:5]1[CH:4]=[C:3]([OH:2])[C:16]2[C:15](=[O:17])[C:14]3[C:9]([S:8][C:7]=2[CH:6]=1)=[CH:10][CH:11]=[CH:12][CH:13]=3

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 510381841-hydroxy-3-(thiiran-2-ylmethoxy)-9H-thioxanthen-9-one

Product 1

HCID 51038186HCID 51038186, compoundYield 71.8%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Aqueous ethyl acetate 1M-HCl (3 mL) was added to 1-hydroxy-3-(thiiran-2-ylmethoxy)-9H-thioxanthen-9-one (10 mg, 0.03 mmol) prepared in Example 8, followed by stirring at room temperature for 3 hours, and the reaction solvent was removed under reduced pressure. Ether was added to the residue, followed by sonication, and the solvent was removed to give the title compound (8 mg, 71.8%) as a yellow solid.

Workup

  1. customthe reaction solvent was removed under reduced pressure
  2. additionEther was added to the residue
  3. customfollowed by sonication
  4. customthe solvent was removed

Sources & evidence

ORD record
ord-82701130821946fca3a48e736be7c1f1
Source dataset
uspto-grants-2014_09
Patent number
US08846749B2

Reaction notes

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