Hydrochloric Acid → 5-{1'-[(8-Cyclopropyl-4-methoxy-quinolin-2-yl)carbonyl]-4-oxospiro[chroman-2,4'-piperidin]-6-yl}nicotinic acid

HRID 831078Notes

Reaction equation

HRID 831078 reaction equation
[CH:28]1([c:31]2[cH:32][cH:33][cH:34][c:35]3[c:36]([O:48][CH3:49])[cH:37][c:38]([C:41](=[O:42])[n:43]4[cH:44][cH:45][n:46][cH:47]4)[n:39][c:40]23)[CH2:29][CH2:30]1.[ClH:1].[ClH:2].[ClH:50].[O:3]=[C:4]1[CH2:5][C:6]2([O:7][c:8]3[cH:9][cH:10][c:11](-[c:14]4[cH:15][n:16][cH:17][c:18]([C:19](=[O:20])[OH:21])[cH:22]4)[cH:12][c:13]31)[CH2:23][CH2:24][NH:25][CH2:26][CH2:27]2.[O:51]=[CH:52][N:53]([CH3:54])[CH3:55].[OH2:56]>>[O:3]=[C:4]1[CH2:5][C:6]2([O:7][c:8]3[cH:9][cH:10][c:11](-[c:14]4[cH:15][n:16][cH:17][c:18]([C:19](=[O:20])[OH:21])[cH:22]4)[cH:12][c:13]31)[CH2:23][CH2:24][N:25]([C:41]([c:38]1[cH:37][c:36]([O:48][CH3:49])[c:35]3[cH:34][cH:33][cH:32][c:31]([CH:28]4[CH2:29][CH2:30]4)[c:40]3[n:39]1)=[O:42])[CH2:26][CH2:27]2

Participants

6

Reactant 5

HCID 313Hydrochloric Acid3×HCID 962WaterHCID 6228DimethylformamideHCID 579308925-(4-oxospiro[3H-chromene-2,4'-piperidine]-6-yl)pyridine-3-carboxylic acidHCID 67170184(8-Cyclopropyl-4-methoxyquinolin-2-yl)(1H-imidazol-1-yl)methanone

Product 1

HCID 160405075-{1'-[(8-Cyclopropyl-4-methoxy-quinolin-2-yl)carbonyl]-4-oxospiro[chroman-2,4'-piperidin]-6-yl}nicotinic acid

Sources & evidence

ORD record
ord-657bbcbe9f85485b9cf4e0e21dd1011c
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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