Hydrochloric Acid → Ethyl 4-[(3-chloro-4-fluorophenyl)amino]-5,7-dihydro-6H-pyrrolo[3',4':4,5]thieno[2,3-d]pyrimidine-6-carboxylate

HRID 831119Notes

Reaction equation

HRID 831119 reaction equation
[CH3:35][CH:36]([OH:37])[CH3:38].[Cl:19][c:20]1[cH:21][c:22]([NH2:23])[cH:24][cH:25][c:26]1[F:27].[Cl:1][c:2]1[c:3]2[c:4]([n:5][cH:6][n:7]1)[s:8][c:9]1[c:10]2[CH2:11][N:12]([C:14](=[O:15])[O:16][CH2:17][CH3:18])[CH2:13]1.[ClH:28].[O:29]1[CH2:30][CH2:31][O:32][CH2:33][CH2:34]1>>[c:2]1([NH:23][c:22]2[cH:21][c:20]([Cl:19])[c:26]([F:27])[cH:25][cH:24]2)[c:3]2[c:4]([n:5][cH:6][n:7]1)[s:8][c:9]1[c:10]2[CH2:11][N:12]([C:14](=[O:15])[O:16][CH2:17][CH3:18])[CH2:13]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 97083-Chloro-4-fluoroanilineHCID 312751,4-DioxaneHCID 58116864Ethyl12-chloro-7-thia-4,9,11-triazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraene-4-carboxylate

Product 1

HCID 58116867Ethyl 4-[(3-chloro-4-fluorophenyl)amino]-5,7-dihydro-6H-pyrrolo[3',4':4,5]thieno[2,3-d]pyrimidine-6-carboxylate

Sources & evidence

ORD record
ord-6d941be9a510410683b152126f1463e7
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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