Tetrahydrofuran → Tert-butyl 4-[3-(hydroxymethyl)phenyl]piperazine-1-carboxylate

HRID 831433Notes

Reaction equation

HRID 831433 reaction equation
[Al+3:23].[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[cH:15][c:16]([CH:20]=[O:21])[cH:17][cH:18][cH:19]2)[CH2:12][CH2:13]1.[CH2:28]1[O:29][CH2:30][CH2:31][CH2:32]1.[H-:22].[H-:25].[H-:26].[H-:27].[Li+:24]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[cH:15][c:16]([CH2:20][OH:21])[cH:17][cH:18][cH:19]2)[CH2:12][CH2:13]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 534027591-Boc-4-(3-Formylphenyl)piperazine

Product 1

HCID 29949342Tert-butyl 4-[3-(hydroxymethyl)phenyl]piperazine-1-carboxylate

Sources & evidence

ORD record
ord-fa13403fbcc34beb9790e12874fc1323
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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