Potassium Cation → 7-(3-Chloropropoxy)-6-methoxy-3-((pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one

HRID 832568Notes

Reaction equation

HRID 832568 reaction equation
[Br:1][CH2:2][CH2:3][CH2:4][Cl:5].[C:28](=[O:29])([O-:30])[O-:31].[K+:32].[K+:33].[O:34]=[CH:35][N:36]([CH3:37])[CH3:38].[OH:6][c:7]1[c:8]([O:26][CH3:27])[cH:9][c:10]2[c:11](=[O:25])[n:12]([CH2:17][O:18][C:19]([C:20]([CH3:21])([CH3:22])[CH3:23])=[O:24])[cH:13][n:14][c:15]2[cH:16]1>>[CH2:2]([CH2:3][CH2:4][Cl:5])[O:6][c:7]1[c:8]([O:26][CH3:27])[cH:9][c:10]2[c:11](=[O:25])[n:12]([CH2:17][O:18][C:19]([C:20]([CH3:21])([CH3:22])[CH3:23])=[O:24])[cH:13][n:14][c:15]2[cH:16]1

Participants

6

Reactant 5

HCID 813Potassium Cation2×HCID 6228DimethylformamideHCID 80061-Bromo-3-chloropropaneHCID 19660Carbonate IonHCID 10804576(7-Hydroxy-6-methoxy-4-oxoquinazolin-3(4H)-yl)methyl pivalate

Product 1

HCID 179427567-(3-Chloropropoxy)-6-methoxy-3-((pivaloyloxy)methyl)-3,4-dihydroquinazolin-4-one

Sources & evidence

ORD record
ord-8f20bf51541046f69e98452999fc5270
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…